Prion
A prion (/ˈpriːɒn/) is an infectious agent, specifically a protein in a misfolded form. The word prion, coined in 1982 by Stanley B. Prusiner, is derived from the words protein and infection. The prot...
Researchers Discover the Moment Alzheimer's disease Is Triggered
Researchers discover the moment Alzheimer's disease is triggered.
Brother And Sister Inherit Disease That Will Stop Them Ever Sleeping Again
A brother and sister have inherited a disease that will stop them from ever sleeping again - and which will eventually kill them. Lachlan and Hayley Webb from Queensland, Australia, suffer from a r...
BBC Future - The tragic fate of the people who stop sleeping
A handful of families are cursed with “fatal insomnia”, a cruel disease that leads to months of sleepless nights and terrible exhaustion. Will a controversial cure save their lives?
Study: Alzheimer’s pathology might be transmittable via medical procedures
Researchers say “seeds” of Alzheimer’s-causing protein may have been carried by tissue extracts or improperly sterilized surgical instruments...
How A History Of Eating Human Brains Protected This Tribe From Brain Disease
The Fore people, a once-isolated tribe in eastern Papua New Guinea, had a long-standing tradition of mortuary feasts — eating the dead from their own community at funerals. Men consumed the flesh of t...
Surgical Exposure to a Brain-Eating Protein: A Small but Unavoidable Risk
Infectious agents called prions can resist standard sterilization and are difficult to diagnose, posing tough challenges for hospitals
Prion
A prion protein is a naturally occurring protein that can be found throughout our bodies, and in high concentrations in the brain. Michael Geschwind, MD PhD,...
Protein folding
Protein folding is the process by which a protein structure assumes its functional shape or conformation. It is the physical process by which a polypeptide folds into its characteristic and functional...
Fungal prions
A fungal prion is a prion that infects fungal hosts. Fungal prions are naturally occurring proteins that can switch between multiple, structurally distinct conformations, at least one of which is self...
Bovine spongiform encephalopathy
Bovine spongiform encephalopathy (BSE), commonly known as mad cow disease, is a fatal neurodegenerative disease (encephalopathy) in cattle that causes a spongy degeneration in the brain and spinal cor...
Chronic wasting disease
Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy (TSE) of mule deer, white-tailed deer, elk (or "wapiti"), and moose ("elk" in Europe). To date, CWD has only been found in me...
Creutzfeldt-Jakob disease
Creutzfeldt–Jakob disease (/ˈkrɔɪtsfɛlt ˈjɑːkoʊb/ KROITS-felt YAH-kohb) or CJD is a degenerative neurological disorder that is incurable and invariably fatal. CJD is at times called a human form...
Exotic ungulate encephalopathy
Exotic ungulate encephalopathy is a transmissible spongiform encephalopathy (TSE), or prion disease, identified in infected organs of zoo animals. This subgroup of the TSEs in captive animals was iden...
Fatal familial insomnia
Fatal familial insomnia (FFI) is a very rare autosomal dominant inherited prion disease of the brain. It is almost always caused by a mutation to the protein PrP, but can also develop spontaneously in...
Feline spongiform encephalopathy
Feline spongiform encephalopathy is a disease that affects the brains of felines. It is caused by proteins called prions.
Feline spongiform encephalopathy (FSE) is a prion disease thought to be re...
Gerstmann-Sträussler-Scheinker syndrome
Gerstmann–Sträussler–Scheinker syndrome (GSS) is a very rare, usually familial, fatal neurodegenerative disease that affects patients from 20 to 60 years in age. This extremely rare disease is classif...
Kuru (disease)
Kuru is an incurable degenerative neurological disorder endemic to tribal regions of Papua New Guinea. It is a type of transmissible spongiform encephalopathy, caused by a prion found in humans.The te...
Scrapie
Scrapie is a fatal, degenerative disease that affects the nervous systems of sheep and goats. It is one of several transmissible spongiform encephalopathies (TSEs), which are related to bovine spongi...
Transmissible mink encephalopathy
Transmissible mink encephalopathy (TME) is a rare sporadic disease that affects the central nervous system of ranch-raised mink. It is classified as a transmissible spongiform encephalopathy, believed...
Transmissible spongiform encephalopathy
Transmissible spongiform encephalopathies (TSEs), also known as prion diseases, are a group of progressive conditions (encephalopathies) that affect the brain and nervous system of many animals, inclu...
Brother And Sister Inherit Disease That Will Stop Them Ever Sleeping Again
A brother and sister have inherited a disease that will stop them from ever sleeping again - and which will eventually kill them. Lachlan and Hayley Webb from Queensland, Australia, suffer from a r...
National Prion Clinic (UK)

Prion diseases comprise Creutzfeldt-Jakob disease (CJD), Gerstmann-Sträussler-Scheinker syndrome, fatal familial insomnia and related disorders. A specialist prion disease clinic was established ...
Stanley B. Prusiner
Stanley Benjamin Prusiner M.D (born May 28, 1942) is an American neurologist and biochemist. Currently the director of the Institute for Neurodegenerative Diseases at University of California, San Fra...
Laura Manuelidis
Laura Manuelidis is a physician and neuropathologist at Yale University. She earned her B.A. degree from Sarah Lawrence College, where she studied poetry, and her M.D. from Yale Medical School. She ...
Circular dichroism
Circular dichroism (CD) is dichroism involving circularly polarized light, i.e., the differential absorption of left- and right-handed light. Left-hand circular (LHC) and right-hand circular (RHC) po...
Surround Optical Fiber Immunoassay (SOFIA)
Surround optical fiber immunoassay (SOFIA) is an ultrasensitive, in vitro diagnostic platform incorporating a surround optical fiber assembly that captures fluorescence emissions from an entire sample...
Sup35p
Sup35p is the Saccharomyces cerevisiae (a yeast) eukaryotic translation release factor. More specifically, it is the yeast eukaryotic release factor 3 (eRF3), which forms the translation termination c...
Protease-sensitive prionopathy
Protease-sensitive prionopathy (PSPr) is a neurodegenerative disorder caused by an abnormal isoform of the prion protein. Contrary to the prions in Creutzfeldt-Jakob disease (CJD), the prions in this ...
Ure2p
Ure2p is a yeast protein that represses transcription of genes involved in nitrogen catabolism. It specifically regulates the utilization of poor nitrogen sources in the presence of preferred nutrient...